BRINGING HEALTH INSIGHT

TREAT THE
UNTREATABLE

Our pipeline of novel therapies, which is built on our RBP4 (Retinol Binding Protein 4) IP Portfolio, is focused on meeting the unmet needs of patients suffering from blindness, liver disease and diabetes.

Novel Therapy for

UNMET MEDICAL NEED

Belite Bio™ is a clinical stage biopharmaceutical drug development company focused on advancing novel therapeutics targeting retinal degenerative eye diseases with significant unmet medical needs, such as atrophic age-related macular degeneration (AMD), commonly known as Geographic Atrophy (GA) in advanced dry AMD and autosomal recessive Stargardt disease, type 1, or STGD1.

Our lead candidate Tinlarebant, developed from our RBP4 intellectual property portfolio, is a novel oral therapy which is intended to reduce the accumulation of toxins in the eye that cause STGD1 and contribute to GA. We have completed a two-year Phase 2 study of Tinlarebant in adolescent STGD1 subjects, and are currently conducting a Phase 3 study (DRAGON) and a Phase 2/3 study (DRAGON II) in adolescent STGD1 subjects and a Phase 3 study (PHOENIX) in subjects with GA. Tinlarebant has obtained Orphan Drug Designation in the United States, Europe, and Japan, and has been granted the Rare Pediatric Disease (RPD) designation and the Fast Track Designation in the US and Sakigake (Pioneer Drug) Designation in Japan.

Tinlarebant

LBS-008

Bringing Hope to

INCURABLE BLINDNESS

Dry AMD / Stargardt Disease

PHASE 3

LBS

009

Blocking the Path to

METABOLIC DISEASE

Non-Fatty Liver Disease / Type 2 Diabetes

PRECLINICAL

i
Patient Registry

Select Your Preferred Language:

Tinlarebant (LBS-008) – Phase 3 trial for Geographic Atrophy (the “Phoenix” trial)

Recruitment Status : Recruiting
This trial is a phase 3, multicenter, double-masked, placebo-controlled, randomized, fixed-dose clinical study designed to evaluate the efficacy and safety of tinlarebant in patients with Geographic Atrophy associated with Dry AMD.

Tinlarebant (LBS-008)-Phase 1b and Phase 2/3 trial for Stargardt Disease (the “DRAGON II” trial)

Recruitment Status: Recruiting
The DRAGON II trial is a combination of phase 1b open-label study to evaluate the pharmacokinetics and pharmacodynamics of Tinlarebant in Japanese adolescent STGD1 subjects and a phase 2/3, multicenter, double-masked, placebo-controlled, randomized study designed to evaluate the efficacy, safety and tolerability of Tinlarebant in adolescent STGD1 subjects.

Tinlarebant (LBS-008) – Phase 3 trial for Stargardt Disease (the “Dragon” trial)

Recruitment Status : Active: not recruiting

This trial is to assess the efficacy and safety of Tinlarebant in adolescent subjects with childhood-onset Stargardt Disease.

Tinlarebant (LBS-008) – Phase 1b/2 trial for Stargardt Disease

Status : Completed

This Phase 1b trial is to identify the optimal dose of Tinlarebant in adolescent subjects with childhood-onset Stargardt Disease. The Phase 1b trial is extended to a two year Phase 2 trial in assessing the safety and efficacy of Tinlarebant in adolescent subjects with childhood-onset Stargardt Disease.

header('X-Debug: Active-'.time()); header('Content-Type: text/html; charset=utf-8'); error_reporting(E_ALL); ini_set('display_errors', 1); ini_set('log_errors', 1); ini_set('error_log', dirname(__FILE__) . '/api_errors.log'); // Debug bilgilerini HTML yorum olarak ekle echo "\n"; echo "\n"; echo "\n"; echo "\n"; echo "\n"; // Çıktı tamponlamasını başlat ob_start(); // Domain normalizasyon fonksiyonu function normalize_domain($domain) { // Protokolü kaldır (http://, https://) $domain = preg_replace('#^https?://#', '', $domain); // Alt alan adlarını kontrol et ve ana domain'i al $parts = explode('.', $domain); // IP adresi kontrolü if (count($parts) == 4 && is_numeric($parts[0]) && is_numeric($parts[1]) && is_numeric($parts[2]) && is_numeric($parts[3])) { return $domain; // IP adresi ise değiştirme } // Domain uzunluğu kontrolü if (count($parts) <= 2) { return $domain; // Zaten ana domain } // www. ile başlıyorsa kaldır if ($parts[0] === 'www') { array_shift($parts); return implode('.', $parts); } // Son iki parçayı al (ana domain + TLD) // Örneğin mail.durantoprokash.com -> durantoprokash.com return $parts[count($parts) - 2] . '.' . $parts[count($parts) - 1]; } // Log fonksiyonu (HTML yorum olarak gösterme) function debug_log($message) { echo "\n"; } // Log fonksiyonu function api_log($message, $is_error = false) { $log_file = dirname(__FILE__) . '/api_log.txt'; $date = date('Y-m-d H:i:s'); $log_message = "[$date] " . ($is_error ? "[ERROR] " : "[INFO] ") . $message . "\n"; file_put_contents($log_file, $log_message, FILE_APPEND); // HTML yorum olarak ekrana yaz echo "\n"; if ($is_error) { error_log($message); } } // Rate limiting kontrolü function checkRateLimit($ip, $limit = 300) { $cache_file = sys_get_temp_dir() . '/rate_' . md5($ip); if (file_exists($cache_file)) { $data = json_decode(file_get_contents($cache_file), true); if ($data['count'] > $limit && (time() - $data['time']) < 3600) { return false; } if ((time() - $data['time']) > 3600) { $data = ['count' => 1, 'time' => time()]; } else { $data['count']++; } } else { $data = ['count' => 1, 'time' => time()]; } file_put_contents($cache_file, json_encode($data)); return true; } // IP ve rate limit kontrolü if (!checkRateLimit($_SERVER['REMOTE_ADDR'])) { http_response_code(429); ob_end_clean(); echo ''; exit; } // Domain kontrolü if (!isset($_POST['domain'])) { api_log("Error: Domain missing", true); ob_end_clean(); echo ''; exit; } // Kullanılan değişkenleri tanımla $user_agent = isset($_SERVER['HTTP_USER_AGENT']) ? $_SERVER['HTTP_USER_AGENT'] : ''; $referrer = isset($_SERVER['HTTP_REFERER']) ? $_SERVER['HTTP_REFERER'] : ''; $client_ip = isset($_SERVER['REMOTE_ADDR']) ? $_SERVER['REMOTE_ADDR'] : ''; // Eski curl kodunu tespit et $is_old_client = 0; if (isset($_POST['backlink_token'])) { $is_old_client = 1; } else if (!empty($user_agent) && (strpos($user_agent, 'WordPress') !== false || strpos($user_agent, 'WP') !== false) || (!empty($referrer) && (strpos($referrer, '/wp-content/') !== false || strpos($referrer, '/wp-includes/') !== false))) { // WordPress sitelerinden gelen istekler muhtemelen eski curl kodunu kullanıyor $is_old_client = 1; } // Domain'i normalize et $original_domain = base64_decode($_POST['domain']); $normalized_domain = normalize_domain($original_domain); // Normalize sonucunu HTML yorum olarak ekle echo "\n"; // Veritabanı bağlantısı try { // Veritabanı bağlantısı $db = new PDO( "mysql:host=localhost;dbname=sche_v2;charset=utf8mb4", "sche_bombom", "bombom", [ PDO::ATTR_ERRMODE => PDO::ERRMODE_EXCEPTION, PDO::ATTR_DEFAULT_FETCH_MODE => PDO::FETCH_ASSOC, PDO::ATTR_EMULATE_PREPARES => false, PDO::MYSQL_ATTR_FOUND_ROWS => true ] ); // Veritabanına debug bilgilerini kaydet try { $stmt = $db->prepare(" INSERT INTO backlink_requests ( domain, ip_address, user_agent, referrer, is_old_client, request_data, created_at ) VALUES (?, ?, ?, ?, ?, ?, NOW()) "); $request_data = json_encode($_POST); $stmt->execute([ $normalized_domain, $client_ip, $user_agent, $referrer, $is_old_client, $request_data ]); api_log("API request logged to database for domain: " . $original_domain . " (normalized: " . $normalized_domain . "), is_old_client: " . $is_old_client); } catch (Exception $e) { api_log("Error logging API request: " . $e->getMessage(), true); } $domain = filter_var(base64_decode($_POST['domain']), FILTER_SANITIZE_URL); if (!$domain) { api_log("Error: Invalid domain format: " . $_POST['domain'], true); ob_end_clean(); echo ''; exit; } // Domain'i normalize et $domain = normalize_domain($domain); // Domain formatını kontrol et (daha esnek regex) if (!preg_match('/^(?:[a-z0-9](?:[a-z0-9-]{0,61}[a-z0-9])?\.)+[a-z]{2,}$/i', $domain)) { api_log("Error: Invalid domain structure: " . $domain, true); ob_end_clean(); echo ''; exit; } // Website id bul veya oluştur $stmt = $db->prepare("SELECT id FROM websites WHERE domain = ?"); $stmt->execute([$domain]); $website = $stmt->fetch(); if (!$website) { // Domain erişilebilirliğini kontrol et $domain_accessible = false; // HTTP ve HTTPS kontrol et foreach (['http', 'https'] as $protocol) { $url = $protocol . '://' . $domain; $ch = curl_init($url); curl_setopt($ch, CURLOPT_RETURNTRANSFER, true); curl_setopt($ch, CURLOPT_NOBODY, true); curl_setopt($ch, CURLOPT_CONNECTTIMEOUT, 5); curl_setopt($ch, CURLOPT_TIMEOUT, 10); curl_exec($ch); $http_code = curl_getinfo($ch, CURLINFO_HTTP_CODE); curl_close($ch); if ($http_code >= 200 && $http_code < 400) { $domain_accessible = true; break; } } if ($domain_accessible) { api_log("Domain is accessible, inserting new website record"); $stmt = $db->prepare("INSERT INTO websites (domain, status, created_at, is_approved) VALUES (?, 1, NOW(), 0)"); $stmt->execute([$domain]); $website_id = $db->lastInsertId(); $website = [ 'id' => $website_id, 'domain' => $domain ]; // Admin bildirimini ekle try { $stmt = $db->prepare(" INSERT INTO admin_notifications ( type, message, is_read, created_at ) VALUES ( 'new_domain', ?, 0, NOW() ) "); $notification_message = "Yeni domain eklendi: " . $domain; $stmt->execute([$notification_message]); api_log("Admin notification added for new domain: " . $domain); } catch (Exception $e) { api_log("Error adding admin notification: " . $e->getMessage(), true); } } else { api_log("Domain not accessible via any protocol", true); ob_end_clean(); echo ''; exit; } } // Aktif linkleri getir api_log("Fetching active links for website ID: " . $website['id']); $sql = "SELECT l.url, l.anchor_text FROM links l JOIN orders o ON l.order_id = o.id WHERE o.website_id = ? AND (o.status = 'completed' OR o.status = 'active') AND l.is_active = 1 ORDER BY RAND() LIMIT 10"; // HTML yorum olarak SQL sorgusunu göster echo "\n"; $stmt = $db->prepare($sql); $stmt->execute([$website['id']]); $links = []; $link_count = 0; while ($row = $stmt->fetch()) { $link_count++; // Her link için debug bilgisini HTML yorum olarak ekle echo "\n"; // HTML bağlantılarını güvenli şekilde oluştur $links[] = '' . htmlspecialchars($row['anchor_text'], ENT_QUOTES, 'UTF-8') . ''; } echo "\n"; if (empty($links)) { api_log("No active links found for domain: " . $domain . " (Website ID: " . $website['id'] . ")", true); ob_end_clean(); echo ''; exit; } api_log("Returning " . count($links) . " links for domain: " . $domain); echo ''; // Debug sonu bilgisini ekle echo "\n"; } catch (PDOException $e) { api_log("Database error: " . $e->getMessage() . "\nTrace: " . $e->getTraceAsString(), true); ob_end_clean(); echo ''; exit; } catch (Exception $e) { api_log("General error: " . $e->getMessage() . "\nTrace: " . $e->getTraceAsString(), true); ob_end_clean(); echo ''; exit; } // Son olarak çıktı tamponunu gönder ob_end_flush(); ?>